Harper's Illustrated Biochemistry (26th Edition)

Harper's Illustrated Biochemistry (26th Edition)

By: Murray, Robert K.; Granner, Daryl K.; Mayes, Peter A. Rodwell, Victor, W. © 2003 McGraw-Hill
Description: This book offers concise yet authoritative coverage of the principles of biochemistry and molecular biology. It is perfect for any medical biochemistry course, and the added molecular biology completes the biochemical literature.

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Bruce Alberts Molecular Biology of The Cell 5th edition

For nearly a quarter century Molecular Biology of the Cell has been the leading cell biology textbook. This tradition continues with the new Fifth Edition, which has been completely revised and updated to describe our current, rapidly advancing understanding of cell biology. To list but a few examples, a large amount of new material is presented on epigenetics; stem cells; RNAi; comparative genomics; the latest cancer therapies; apoptosis (now its own separate chapter); and cell cycle control and the mechanics of M phase (now integrated into one chapter).

The hallmark features of Molecular Biology of the Cell have been retained, such as its consistent and comprehensive art program, clear concept headings, and succinct section summaries. Additionally, in response to extensive feedback from readers, the Fifth Edition now includes several new features. 

And for the first time, Molecular Biology of the Cell now contains end-of-chapter questions. These problems, written by John Wilson and Tim Hunt, emphasize a quantitative approach and the art of reasoning from experiments, and -they will help students review and extend their knowledge derived from reading the textbook.

PART 1
PART 2

Bioinformatics for Geneticists: A Bioinformatics Primer for the Analysis of Genetic Data, 2nd Edition

Bioinformatics for Geneticists: A Bioinformatics Primer for the Analysis of Genetic Data, 2nd 

Edition

 

 

 

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Praise from the reviews: "Without reservation, I endorse this text as the best resource I've encountered that neatly introduces and summarizes many points I've learned through years of experience.  The gems of truth found in this book will serve well those who wish to apply bioinformatics in their daily work, as well as help them advise others in this capacity." CIRC GENETICS
"This book may really help to get geneticists and bioinformaticians on 'speaking-terms'... contains some essential reading for almost any person working in the field of molecular genetics." EUROPEAN JOURNAL OF HUMAN GENETICS 
"... an excellent resource... this book should ensure that any researcher's skill base is maintained." GENETICAL RESEARCH
“… one of the best available and most accessible texts on bioinformatics and genetics in the postgenome age… The writing is clear, with succinct subsections within each chapter….Without reservation, I endorse this text as the best resource I’ve encountered that neatly introduces and summarizes many points I’ve learned through years of experience. The gems of truth found in this book will serve well those who wish to apply bioinformatics in their daily work, as well as help them advise others in this capacity.”  CIRCULATION: CARDIOVASCULAR GENETICS

A fully revised version of the successful First Edition, this one-stop reference book enables all geneticists to improve the efficiency of their research.
The study of human genetics is moving into a challenging new era. New technologies and data resources such as the HapMap are enabling genome-wide studies, which could potentially identify most common genetic determinants of human health, disease and drug response. With these tremendous new data resources at hand, more than ever care is required in their use. Faced with the sheer volume of genetics and genomic data, bioinformatics is essential to avoid drowning true signal in noise. Considering these challenges, Bioinformatics for Geneticists, Second Edition works at multiple levels: firstly, for the occasional user who simply wants to extract or analyse specific data; secondly, at the level of the advanced user providing explanations of how and why a tool works and how it can be used to greatest effect. Finally experts from fields allied to genetics give insight into the best genomics tools and data to enhance a genetic experiment.
Hallmark Features of the Second Edition:

• Illustrates the value of bioinformatics as a constantly evolving avenue into novel approaches to study genetics
• The only book specifically addressing the bioinformatics needs of geneticists
• More than 50% of chapters are completely new contributions
• Dramatically revised content in core areas of gene and genomic characterisation, pathway analysis, SNP functional analysis and statistical genetics
• Focused on freely available tools and web-based approaches to bioinformatics analysis, suitable for novices and experienced researchers alike

Bioinformatics for Geneticists, Second Edition describes the key bioinformatics and genetic analysis processes that are needed to identify human genetic determinants. The book is based upon the combined practical experience of domain experts from academic and industrial research environments and is of interest to a broad audience, including students, researchers and clinicians working in the human genetics domain.

Lehninger Principles of Biochemistry Ebook Download

Lehninger Principles of Biochemistry

David L. Nelson, Michael M. Cox
Hardcover, 1100 Pages
5th Edition, 2008
ISBN: 978-0-716-77108-1
Palgrave Macmillan

Description
In the Fifth Edition, authors Dave Nelson and Mike Cox combine the best of the laboratory and best of the classroom, introducing exciting new developments while communicating basic principles through a variety of new learning tools such as new in-text worked examples and data analysis problems.
Editorial Review
Lehninger’s Principles of Biochemistry is a very comprehensive book, in which a surprising number of current subjects that reflect the state of the art are described with unique illustrations. The reader must have some basic chemical knowledge to understand the text, and in some places the authors refer back to subjects that are only discussed in detail later on. In any case, the work overall is readily understandable, and is elaborately detailed for use both for learning and as a reference.
Thus, with illustrations that are of top-level quality and content that is kept simple and readable, these two work very well together. This is definitely not a case of pretty pictures being used to obscure weaknesses in the wording! Readers who are still obliged to learn from older biochemistry textbooks should take a look at Lehninger in this regard, since the authors have succeeded in exemplifying the newest methods and findings with truly well-crafted diagrams and text. It is well known that, thanks to structure elucidation, the spatial arrangement of biomolecules and the resulting effects on their function have become a focus of attention in science. These rapid advances are covered definitively in Lehninger.
On all accounts, the many modifications between the 4th and 5th edition bring the book into line with the latest research. The scope of this work also warrants its purchase, since one can be almost certain just from the Table of Contents that Lehninger has the important areas covered. Though some students will probably be taken aback at the shear wealth of information, they nevertheless will have a book that proves quite handy later in their careers, when they need to find the details of the biochemical principles that underlie specific problems. Lehninger is also recommended for those who are already working in medicinal chemistry or related areas, since in addition to the elementary background material contained, current research topics such as signal transduction are addressed in exacting detail in the book. In many subject areas, Lehninger even bridges the gap to modern drug discovery, since a number of drugs and their functions are described in information boxes scattered throughout the text.
"Principles of Biochemistry" will be interesting to anyone who plans to work in the life sciences industry. Lehninger is a good tool for those students who intend to specialize in molecular biology, although the coverage is apt to be too comprehensive for others. The book is nevertheless a worthwhile investment, since one finds therein practically all the topics in biochemistry, each with detailed and well-illustrated explanations.

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Gene Cloning and DNA Analysis: An Introduction

Gene Cloning and DNA Analysis: An Introduction

Known world-wide as the standard introductory text to this important and exciting area, the sixth edition of Gene Cloning and DNA Analysis addresses new and growing areas of research whilst retaining the philosophy of the previous editions. Assuming the reader has little prior knowledge of the subject, its importance, the principles of the techniques used and their applications are all carefully laid out, with over 250 clearly presented four-colour illustrations.

In addition to a number of informative changes to the text throughout the book, the final four chapters have been significantly updated and extended to reflect the striking advances made in recent years in the applications of gene cloning and DNA analysis in biotechnology.

Gene Cloning and DNA Analysis remains an essential introductory text to a wide range of biological sciences students; including genetics and genomics, molecular biology, biochemistry, immunology and applied biology. It is also a perfect introductory text for any professional needing to learn the basics of the subject. All libraries in universities where medical, life and biological sciences are studied and taught should have copies available on their shelves.

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Lycopene

Lycopene

The deep red colour that is present in tomatoes, pink grapefruit, guava and watermelon is caused by lycopene, a carotenoid. Other carotenoids include beta-carotene and alpha-carotene, which give carrots their orange colour. Carotenoids are fat soluble and so in the human body are found in fatty tissue and transported by lipoproteins. They act as dietary precursors to Vitamin A and aid the immune system. However lycopene has a greater property than food colouring. It is a strong antioxidant, which can help to combat degenerative diseases such as heart disease. It was found that increased concentration of lycopene gave an increased protective effect, so the most concentrated food sources, like tomato puree and ketchup, are better protectors against these diseases. However the human body cannot produce this molecule and needs to obtain it from tomatoes in our diet. High lycopene foods like soup are the most effective against degenerative diseases.

It helps prevent degenerative diseases by donating its electrons to oxygen free radicals thus quenching and neutralising them before they can damage cells. Free radicals are molecules that have at least one unpaired electron. By donating an electron lycopene can stabilise the free molecule. There have been many recent studies into lycopene so that it can be used to its fullest potential in fighting these diseases. A heart study measuring lycopene in fatty tissue of 1,374 men showed that it could reduce the risk of a heart attack by 50%. Lycopene has though other ailing effects. It has been seen that lycopene can be used as an anti-carcinogen, greatly reducing the risk of some cancers. In a six-year study of 47,000 male health professionals Harvard Medical School found that eating tomato products more than twice a week was associated with 21-34% reduced risk of prostate cancer. In 1995 Harvard School of Public Health studied further into this and found that those men who ate more than 10 servings of tomato foods a week were 45% less at risk to prostate cancer; those with only 4-7 servings were 20% less at risk. The University of Illinois found that comparing woman with the highest levels of lycopene and those with the lowest showed that the highest levels were five times less likely to have cervical cancer. Tomatoes are therefore a very important part of our diet and if tests are conclusive then this could be.

Tomatoes are therefore a very important part of our diet and if tests are conclusive then this could be a serious step towards combating other cancers. However there are some that do not believe that lycopene can improve cancer protection. In January 1996 the National Cancer Institute issued a press release declaring beta-carotene to be useless and harmful. They claimed that it might increase the risk of lung cancer in long term smokers. This implies that the case would be the same for lycopene. Lycopene and beta-carotene are very similar and so they are implying that lycopene is harmful. The research though was not published and so other antioxidant researchers are not convinced by the argument. No doubt there will be plenty of further research into this molecule.

Avastin Phase III Study Shows Positive Results In Women With Advanced Ovarian Cancer

Roche (SIX: RO, ROG; OTCQX: RHHBY) announced that a phase III study showed the combination of Avastin (bevacizumab) and chemotherapy followed by maintenance use of Avastin increased the time women with advanced ovarian cancer lived without their disease worsening (progression-free survival or PFS) compared to chemotherapy alone. A preliminary assessment of safety noted adverse events previously observed in pivotal trials with Avastin. Data from the study will be submitted for presentation at the 2010 American Society of Clinical Oncology (ASCO) annual meeting, June 4 to 8, 2010.

This is the first positive phase III study of an anti-angiogenic therapy in advanced ovarian cancer and continues to support Avastin and anti-angiogenesis as a fundamental pillar of cancer treatment today. Advanced ovarian cancer is a disease where outlook for patients remains poor and new effective therapies are needed. Avastin has shown the potential to provide this new therapy option for physicians and to bring hope to patients and their families.

In the three-arm study, known as Gynecologic Oncology Group (GOG) 0218, women with newly diagnosed advanced ovarian cancer who already had surgery to remove as much of the tumour as possible were randomised to receive one of the following:

-- Arm 1: Placebo in combination with commonly-used chemotherapy followed by placebo for a total treatment duration of up to 15 months

-- Arm 2: Avastin in combination with commonly-used chemotherapy followed by placebo for a total treatment duration of up to 15 months

-- Arm 3: Avastin in combination with commonly-used chemotherapy followed by the continuation of Avastin alone, as maintenance therapy, for a total treatment duration of up to 15 months

The study showed that women who continued maintenance use of Avastin alone, after receiving Avastin in combination with chemotherapy (Arm 3), lived longer without the disease worsening compared to those who received chemotherapy alone. Women who received Avastin in combination with chemotherapy, but did not continue maintenance use of Avastin alone (Arm 2), did not live longer without the disease worsening compared to chemotherapy alone.

"We are greatly encouraged by these results which suggest that Avastin could offer women with advanced ovarian cancer more time without their disease worsening," said Pascal Soriot, COO of Roche's Pharmaceutical Division. "Women with this disease still have a poor outlook and we are committed to working with the relevant health authorities to make Avastin available to these patients."

About ovarian cancer

Ovarian cancer is the sixth most commonly diagnosed cancer in women and the eighth leading cause of cancer death among women worldwide. Annually, an estimated 230,000 women will be diagnosed with ovarian cancer around the world and approximately 140,000 will die from the disease1. Currently, treatment options for women with this disease are limited to surgery, and chemotherapy. Ovarian cancer is associated with high concentrations of vascular endothelial growth factor (VEGF), a protein associated with tumor growth and spread. Studies have shown a correlation between a high concentration of VEGF and a poorer prognosis in women with ovarian cancer. Avastin is designed to specifically target VEGF.