Dr. Atanasio Pandiella. Investigador científico del CSIC Centro de Investigación del Cáncer (Universidad de Salamanca-CSIC)
HER/ErbB receptors play important roles in animal physiology, and their deregulation may lead to diseases such as cancer. For this reason, the study of their function represents an important field of research in the biomedical arena. We have approached the study of HER receptor signalling by genomic and proteomic techniques, which allowed us to uncover novel signalling intermediates of the HER pathway. We will discuss the identification of some of these intermediates,a s well as the strategies that led to their identification. We will exemplify our studies in the discovery of P-REX, a guanine nucleotide exchange factor which plays a role in the activation of Rac upon HER receptor stimulation. The mechanism of P-Rex activation, as well as its biological significance will be discussed. We will also show evidence linking P-Rex expression to patient out come in breast cancer
HER/ErbB receptors play important roles in animal physiology, and their deregulation may lead to diseases such as cancer. For this reason, the study of their function represents an important field of research in the biomedical arena. We have approached the study of HER receptor signalling by genomic and proteomic techniques, which allowed us to uncover novel signalling intermediates of the HER pathway. We will discuss the identification of some of these intermediates,a s well as the strategies that led to their identification. We will exemplify our studies in the discovery of P-REX, a guanine nucleotide exchange factor which plays a role in the activation of Rac upon HER receptor stimulation. The mechanism of P-Rex activation, as well as its biological significance will be discussed. We will also show evidence linking P-Rex expression to patient out come in breast cancer
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